Predictors of therapeutic response in schizophrenia – preliminary results

Introduction Schizophrenia is a heterogenous disease and there wide variation in the therapeutic response patients, with some being good responders others - severely disabled defined as treatment resistant. Objectives To identify specific socio-demographic clinical characteristics prognostic factors for search of course prognosis outcome. Methods The study has naturalistic, non-interventional design includes one-year prospective follow-up. Schizophrenic patients are evaluated three time points – at admission (T1), by discharge (T2), one year after hospitalization (T3). Psychopathology Positive Negative Syndrome Scale (PANSS), well negative symptoms Assessment Symptoms (SANS), aggression Modified Overt Aggression (MOAS) functioning GlobalAssessment Functioning (GAF). Statistical analyses performed using Descriptive methods, Student’s t-test, Wilcoxon Signed Ranks Test, multiple regression. An ethical approval been obtained. Results sample consists 108 mean age 39 (SD±12.7) 89.8 % (N=97) them were prospectively assessed year. All symptom dimensions 5 -factor model positive, negative, disorganized, manic, depressive, measured PANSS, (objectified SANS) MOAS) significantly lower inpatient treatment. There an improvement (z=-8.01, p<.001), although both (z=-2,45, p=0.015) aggressive behavior (z=-4.260, p<.001) higher discharge. From regression, T1, involuntary significant predictor (p<.001). duration longer compliance (p=.022) atypical antipsychotics decreases hospital stay (p=.021). One admission, employment serves positive predictive factor it psychopathology (p=.001), (p<.001), improves Good (p=.015), less Conclusions efficacious terms psychopathology, linked to better functioning. naturalistic shows depletion effects probably due incomplete medication compliance, which bad This implies need continuous psychosocial services psychoeducation Disclosure Interest None Declared